Volume 12, Issue 2 (9-2025)
NBR 2025, 12(2): 0-0 |
Back to browse issues page
Ethics code: IR.PNU.REC.1403.223
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mesbahi bidgoli M, Fazilati M, Rahmani A, Nazem H. Evaluating the effect of ozone in reducing the toxicity of corn contaminated with ochratoxin A in Wistar rats. NBR 2025; 12 (2)
URL: http://nbr.khu.ac.ir/article-1-3732-en.html
URL: http://nbr.khu.ac.ir/article-1-3732-en.html
Department of Food, Halal and Agricultural Products, Food Technology and Agricultural Products Research Center, Standard Research Institute (SRI), Karaj, Iran. , .rahmani@standard.ac.ir
Abstract: (40 Views)
Objective: Ozone treatment has been recognized as an effective approach to significantly reduce mycotoxin levels, including ochratoxin A (OTA), in agricultural products. This study aimed to evaluate the safety of untreated and ozone-treated OTA-contaminated corn (OCC) through a sub-chronic toxicity assessment in rats.
Method: Male rats were randomly assigned into one control group and three experimental diet groups. The experimental groups received untreated OCC or ozone-treated OCC through oral administration for a 30-day period. Clinical signs, survival, hematological parameters, serum biochemical indices, and histopathological alterations of liver and kidney tissues were examined to evaluate potential toxicological effects.
Results: No mortality or overt clinical abnormalities were observed during the experimental period. Rats fed untreated OCC exhibited significant decreases in white blood cell (WBC) counts and marked elevations in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels. Histopathological evaluation revealed OTA-induced lesions in both liver and kidney tissues. In contrast, rats fed ozone-treated OCC showed reduced biochemical alterations and attenuated histopathological damage compared with those receiving untreated OCC.
Method: Male rats were randomly assigned into one control group and three experimental diet groups. The experimental groups received untreated OCC or ozone-treated OCC through oral administration for a 30-day period. Clinical signs, survival, hematological parameters, serum biochemical indices, and histopathological alterations of liver and kidney tissues were examined to evaluate potential toxicological effects.
Results: No mortality or overt clinical abnormalities were observed during the experimental period. Rats fed untreated OCC exhibited significant decreases in white blood cell (WBC) counts and marked elevations in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels. Histopathological evaluation revealed OTA-induced lesions in both liver and kidney tissues. In contrast, rats fed ozone-treated OCC showed reduced biochemical alterations and attenuated histopathological damage compared with those receiving untreated OCC.
Type of Study: Original Article |
Subject:
Animal Biology
Received: 2025/05/5 | Revised: 2025/09/27 | Accepted: 2025/09/27 | Published: 2025/09/1 | ePublished: 2025/09/1
Received: 2025/05/5 | Revised: 2025/09/27 | Accepted: 2025/09/27 | Published: 2025/09/1 | ePublished: 2025/09/1
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
© 2025 CC BY-NC 4.0 | Nova Biologica Reperta
Designed & Developed by : Yektaweb