Nova Biologica Reperta

Comparison of uric acid serum level and other risk factors in patients with hypertrophic cardiomyopathy with healthy people

Authors

mohammadtaghi hedayati
mohammadreza zahmatkesh
kamyar amin
hemmat gholinia
https://doi.org/10.22034/NBR.12.4.6
Abstract
Introduction:Hypertrophic cardiomyopathy(HCM)is a common inherited disease that can lead to acute cardiac complications.Since uric acid level is recognized as a long-term predictor for some cardiac diseases,this study aimed to compare serum uric acid levels and other risk factors between patients with HCM and healthy individuals.

Methods:This cross-sectional study was conducted on100individuals referred to a cardiology clinic.Participants were divided into two groups of50:those diagnosed with hypertrophic cardiomyopathy and non-affected individuals,who were followed for one year.Patients were compared based on age, history of alcohol consumption,myocardial infarction,and measured uric acid levels.

Results:The study found that variables such as age(P<0.001), body mass index(BMI)(P=0.017), history of alcohol consumption(P=0.006),repeat percutaneous coronary intervention (PCI)(P=0.022),myocardial infarction(P=0.041),and cardiac-related death(P=0.003)were significantly associated with HCM patients compared to the control group. Overall, major adverse cardiac events(MACE)were also significantly linked to the case group(P<0.001).However,no significant association was found between uric acid levels and any of the variables.In the long-term analysis,smoking was the only factor that increased the risk of cardiovascular events by nearly27-fold.

Conclusion:The results indicated that age, history of alcohol consumption, and prior myocardial infarction are risk factors associated with HCM.Uric acid levels did not prove to be a predictor of cardiovascular events within one year in patients with hypertrophic cardiomyopathy.

Keywords

Hypertrophic cardiomyopathy
HCM
Percutaneous coronary intervention
PCI
Uric acid
SUA

  • Receive Date 08 June 2026
  • Publish Date 08 June 2026

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