Effect of Urtica dioica hydroalcoholic extract on liver inflammatory factors in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate

Tayanloo, Akram; Zare1, Samad; Karimzadeh-Bardei, Latifeh; Hoseini, Serwa

doi:10.21859/acadpub.nbr.4.2.181

Effect of Urtica dioica hydroalcoholic extract on liver inflammatory factors in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate

Authors

Akram Tayanloo ¹

Samad Zare1 ¹

Latifeh Karimzadeh-Bardei ²

Serwa Hoseini ²

¹ Urmia University

² Kharazmi University

https://doi.org/10.21859/acadpub.nbr.4.2.181

Abstract

The polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women at childbearing age. Metabolic syndrome is present from 28% to 46% of patients with PCOS. Non-alcoholic fatty liver di-sease (NAFLD) is considered the hepatic expression of metabolic syndrome. In this study Urtica dioica moderator ef-fect on liver function in PCOS rats was examined. 120 adult female Wistar rats were divided into control, PCOS and nettle-treated groups. The PCOS group was injected subcutaneously 2 mg/kg estradiol valerate. After confirmed poly-cystic in ovaries, the experimental group was injected of the nettle extract doses (150,250, 450 mg/kg BW). Then rats were killed and blood samples were evaluated. Data were analyzed using ANOVA one-way and p<0.05 was considered statistically significant. ELISA test showed a decrease in IL-6 level and CRP levels reduced in PCOS rats were treated with various concentrations of nettle. Our results show that nettle due to its antioxidant properties reduce the levels of IL-6 and CRP in nettle extract treated-PCOS compared to the PCOS.

Keywords

fatty liver

inflammation

ovary

ELISA

20.1001.1.24236330.1396.4.2.10.3

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