Volume 4, Issue 4 (3-2018)                   nbr 2018, 4(4): 353-360 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Yari S, Karamian R, Asabbeigi M, Namdari A. Protective effect of Arctium lappa on oxidative stress and nephrotoxicity induced by gentamicin. nbr 2018; 4 (4) :353-360
URL: http://nbr.khu.ac.ir/article-1-3057-en.html
Protective effect of Arctium lappa on oxidative stress and nephrotoxicity induced by gentamicin
Siamak Yari * , Roya Karamian , Mostafa Asabbeigi , Ali Namdari
Bu-Ali Sina University, Hamedan
Abstract:   (5548 Views)
This study aimed to investigate the protective effect of Arctium lappa (AL) on gentamicin (GM)-induced nephrotoxicity in rats. Twenty-four Wistar rats were divided into four groups including: control group; GM group (intrapritoneal injection, IP, of 100 mg/kg GM B.W.); GM+AL group (received IP injection of 100 mg/kg GM and 500 mg/kg AL orally) and AL group (received 500 mg/kg AL orally). The experimental period lasted for 10 days. Nephrotoxicity was biochemically and histologically evaluated. The concentrations of creatinine, urea, malondialdehyde (MDA), superoxide dismutase (SOD) and peroxide hydrogen (H2O2) in the serum samples were determined. Moreover, histological examinations were performed. The animals treated with gentamicin showed significantly higher serum urea, creatinine, MDA and H2O2 levels and lower SOD activity. However, co-administration of AL produced amelioration in biochemical indices of nephrotoxicity in serum. Histomorphological examination showed necrosis and desquamation of tubular epithelial cells in the renal cortex in animals treated with gentamicin whereas simultaneous administration of AL and GM reduced histological damages. The data obtained suggest that treatment with AL extract can help to reduce gentamicin-induced nephrotoxicity.
 
 
 
Keywords: creatinine, hydrogen peroxide, kidney tissue, malondialdehyde, rat
Full-Text [PDF 570 kb]   (1764 Downloads)    
Type of Study: Original Article | Subject: Plant Biology
Received: 2017/08/8 | Revised: 2018/05/9 | Accepted: 2018/01/8 | Published: 2018/03/19 | ePublished: 2018/03/19
References
1. Abdel-Naim, A.B., Abdel-Wahab, M.H., and Attia, F.F. 1999. Protective effects of vitamin E and probucol against gentamicin-induced nephrotoxicity in rats. – Pharmacol. Res. 40: 183-187.
2. Awale, S., Lu, J., Kalauni, S.K., Kurashima, Y., Tezuka, Y., Kadota, S., and Esumi, H. 2006. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. – Cancer Res. 66:1751-1757.
3. Baliga, R., Ueda, N., Walker, P.D., and Shah, S.V. 1999. Oxidant mechanisms in toxic acute renal failure. – Drug Metab. Rev. 31: 971-997.
4. Baryla, A., Laborde, C., Montillet, J.L., Triantaphylides, C. and Chagvardieff, P. 2000. Evaluation of lipid peroxidation as a toxicity bioassay for plants exposed to copper. – Environ. Pollut. 109: 131-135.
5. Basnakian, A.G., Kaushal, G.P. and Shah, S.V. 2002. Apoptotic pathways of oxidative damage to renal tubular epithelial cells. – Antioxid. Redox. Signal 4: 915-924.
6. Edwards, C.Q., Smith, C. R., Baughman, K. L., Rogers, J.F., and Lietman, P.S. 1976. Concentrations of gentamicin and amikacin in human kidneys. – Antimicrob. Agents Chemother. 9: 925-927.
7. Eisenberg, J.M., Koffer, H., Glick, H.A., Connell, M.L., Loss, L.E., Talbot, G.H., and Strom, B.L. 1987. What is the cost of nephrotoxicity associated with aminoglycosides? – Ann. Intern. Med. 107: 900-909.
8. Galdino, P.M., Alexandre, L.N., Pacheco, L.F., Junior, R.D.S.L., de Paula, J.R., Pedrino, G.R., and Ferreira, P.M. 2017. Nephroprotective effect of Rudgea viburnoides (Cham.) Benth. leaves on gentamicin-induced nephrotoxicity in rats. – J. Ethnopharmacol. 201: 100-107.
9. Hirose, M., Yamaguchi, T., Lin, C., Kimoto, N., Futakuchi, M., Kono, T., Nishibe, S. and Shirai, T. 2000. Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague–Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. – Cancer Lett. 155: 79-88.
10. Houghton, D.C., Plamp 3rd, C.E., DeFehr, J.M., Bennett, W.M., Porter, G., and Gilbert, D. 1978. Gentamicin and tobramycin nephrotoxicity. A morphologic and functional comparison in the rat. – Am. J. Pathol. 93: 137-152.
11. Humes, H.D. 1988. Aminoglycoside nephrotoxicity. – Kidney International. 33: 900-911.
12. Juan, S.H., Chen, C.H., Hsu, Y.H., Hou, C.C., Chen, T.H., Lin, H., Chu, Y.L. and Sue, Y.M. 2006. Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. – Nephrol Dial Transplant. 22: 732-739.
13. Karataş, Y., Seçilmiş, M.A., Karayaylalı, İ., Doran, F., Büyükafşar, K., Şingirik, E., Saglıker, Y. and Dikmen, A., 2004. Effect of tempol (4‐hydroxy tempo) on gentamicin‐induced nephrotoxicity in rats. – Fundam Clin Pharmacol. 18: 79-83.
14. Kuhad, A., Tirkey, N., Pilkhwal, S., and Chopra, K. 2006. Effect of Spirulina, a blue green algae, on gentamicin‐induced oxidative stress and renal dysfunction in rats. – Fundamental & Clinical Pharmacology. 20: 121-128.
15. Luft, F.C. 1974. Renal parenchymal accumulation of aminoglycoside antibiotics in rats. – J. Infect. Dis. 130: 656-659.
16. Luft, F.C., Bloch, R., Sloan, R.S., Yum, M.N., Costello, R. and Maxwell, D.R. 1978. Comparative nephrotoxicity of aminoglycoside antibiotics in rats. – J. Infect. Dis. 138: 541-545.
17. Maldonado, P.D., Barrera, D., Medina-Campos, O.N., Hernández-Pando, R., Ibarra-Rubio, M.E., and Pedraza-Chaverrı́, J. 2003. Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats. – Life Sci. 73: 2543-2556.
18. Maldonado, P.D., Barrera, D., Rivero, I., Mata, R., Medina-Campos, O.N., Hernández-Pando, R., and Pedraza-Chaverrí, J. 2003. Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage. – Free Radic. Biol. Med. 35: 317-324.
19. McCall, M.R., and Frei, B. 1999. Can antioxidant vitamins materially reduce oxidative damage in humans? – ‎Free Radic. Biol. Med. 26: 1034-1053.
20. Mingeot-Leclercq, M.P. and Tulkens, P.M. 1999. Aminoglycosides: nephrotoxicity. – Antimicrob. Agents Chemother. 43: 1003-1012.
21. Mitsuo, M., Nobuo, Y., and Katsuya, T. 2005. Inhibitory compounds of alpha glucosidase activity from Arctium lappa L. – J. Oleo. Sci. 54: 589-594
22. Miyamoto, K., Nomura, M., Sasakura, M., Matsui, E., Koshiura, R., Murayama, T., Furukawa, T., Hatano, T., Yoshida, T., and Okuda, T. 1993 Antitumor-activity of oenothein-B, a unique macrocyclic ellagitannin. – Japanian J. Cancer Res. 84: 99-103.
23. Moreira, M.A., Nascimento, M.A., Bozzo, T.A., Cintra, A., da Silva, S.M., Dalboni, M.A., and Higa, E.M. 2014. Ascorbic acid reduces gentamicin-induced nephrotoxicity in rats through the control of reactive oxygen species. – Clin. Nutr. 33: 296-301.
24. Morita, T., Ebihara, K., and Kiriyama, S. 1993. Dietary fiber and fat derivatives prevent mineral-oil toxicity in rats by the same mechanism. – J. Nutr. 123: 1575-1585.
25. Park, S.Y., Hong, S.S., Han, X.H., Hwang, J.S., Lee, D., Ro, J.S., and Hwang, B.Y. 2007. Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production. – Chem. Pharm. Bull. 55: 150-152.
26. Parlakpinar, H., Tasdemir, S., Polat, A., Bay-Karabulut, A., Vardi, N., Ucar, M., and Acet, A. 2005. Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. – Toxicology 207: 169-177.
27. Schentag, J.J., Jusko, W.J., Vance, J.W., Cumbo, T.J., Abrutyn, E., DeLattre, M., and Gerbracht, L.M. 1977. Gentamicin disposition and tissue accumulation on multiple dosing. – J. Pharmacokinet. Biopharm. 5: 559-577.
28. Servais, H., Ortiz, A., Devuyst, O., Denamur, S., Tulkens, P.M. and Mingeot-Leclercq, M.P., 2008. Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation. – Apoptosis 13: 11-32.
29. Stahl, W., and Sies, H. 2003. Antioxidant activity of carotenoids. – Mol. Aspects Med. 24: 345-351.
30. Velikova, V., Yordanov, I. and Edreva, A. 2000. Oxidative stress and some antioxidant systems in acid rain-treated bean plants: protective role of exogenous polyamines. – Plant Sci. 151: 59-66.
31. Walker, P.D., Barri, Y., and Shah, S.V. 1999. Oxidant mechanisms in gentamicin nephrotoxicity. – Renal failure 21: 433-442.
Add your comments about this article : Your username or Email:
CAPTCHA
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons Licence
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



© 2024 CC BY-NC 4.0 | Nova Biologica Reperta

Designed & Developed by : Yektaweb