TY - JOUR JF - nbr JO - NBR VL - 5 IS - 2 PY - 2018 Y1 - 2018/9/01 TI - The phytochemical study and antiprolifrative effect of hydroalcoholic extract of Adiantum capillus-veneris L. on MCF-7 and MRC-5 cell lines TT - مطالعۀ فیتوشیمیایی و اثر ضدتکثیری عصارۀ هیدروالکلی گیاه پرسیاوشان روی رده های سلولی MCF-7 و MRC-5 N2 - With the increase of cancer disease and the side-effects of the current treatments, researchers are attempting to find methods with less side-effect. The fern Adiantum capillus-veneris L. has triterpenoid compounds which have anti-tumor characteristics. This study aims to investigate the fatal effect of the extract of this plant on breast cancer (MCF-7) and normal (MRC-5) cell lines using MTT method. A. capillus-veneris specimens were collected from Marzoon Abad Village and were dried at the temperature of 40° C by the use of Soxhlet and Ethanol % 96. Hydroalcoholic extract was produced from the aerial and underground parts of this plant and 3 fractions, i.e., Hexane, Chloroform and Ethyl acetate, were prepared from the extract. The compounds of the plant extract were identified by GC-Mass. The results demonstrate the presence of polyphenolic compounds, terpenoid, fatty acids, wax, alkaloid, N-oxide and fibers, with strong antioxidant effect. The results of the MTT test proved that this extract had a dose-depending fatal effect on the MCF-7 cells and is capable of eradicating the cancer cells. On the other hand, its effect on cancer cells is more than its effect on normal cells. Also, IC50 in both of cell lines induced by the extracts of aerial and underground parts showed a significant difference. The fatal characteristics of the extract are comparable with the cisplatin anti-cancer drug. SP - 118 EP - 127 AU - Hassanpour, Hesane AU - Shokrzadeh Lamuki, Mohammad AU - Tabari, Reza AU - Rezaee, Fatemeh AU - Rezaee, Fatereh AD - Babol branch of Azad University KW - antioxidant KW - breast cancer KW - cisplatin KW - GC-Mass KW - Polypodiaceae UR - http://nbr.khu.ac.ir/article-1-3059-en.html DO - 10.29252/nbr.5.2.118 ER -