TY - JOUR T1 - The multidrug resistance and production of extended-spectrum beta-lactamases ctx-m, per and ver in Escherichia coli isolates derived from raw dairy samples TT - مقاومت چندگانه، اشرشیا کلی تولیدکننده بتالاکتامازهای طیف گسترده per ،ctx-m و veb جدا شده از فراورده ­های لبنی خام JF - nbr JO - nbr VL - 7 IS - 1 UR - http://nbr.khu.ac.ir/article-1-2931-en.html Y1 - 2020 SP - 46 EP - 54 KW - antibiotic KW - bacteria KW - gene KW - raw milk KW - unprocessed cheese N2 - The occurrence of extended-spectrum beta-lactamases-producing bacteria is an important public health issue. The aim of this study was to investigate phenotypic and genotypic characteristics regarding the presence of extended spectrum β-lactamase ctx-m, per and ver producing Escherichia coli isolated from raw dairy samples. For this purpose, E. coli were isolated from 247 raw dairy samples (milk and cheese) in Yasooj in 2015-2017, and the isolates were screened for antibiotic resistance, extended spectrum β-lactamase and the presence of ctx-m, per and ver. In total, 200 isolates were selected. The highest frequency of resistance in isolates was against tetracycline (96.5%) and ampicillin (95.5%) antibiotics and the lowest against imipenem (12.5%), In addition, multidrug resistance against four or more antibiotics was observed in some isolates. Extended spectrum β-lactamase resistance was detected in 86 isolates (43%) and ctx-m, per and ver genes were detected in 82, 0 and 7 E. coli isolates, respectively. These findings demonstrated that raw dairy products may be reservoirs for the dissemination of β-lactam antibiotics and that resistance genes could be transmitted to humans through the food chain. M3 10.29252/nbr.7.1.46 ER -