RT - Journal Article T1 - Anti-depressive effects of hydro-alcoholic extract of Chevilan (Ferulago angulate Boiss.) in adult male wistar rat model of ischemia/ hypoperfusion JF - nbr YR - 2018 JO - nbr VO - 5 IS - 2 UR - http://nbr.khu.ac.ir/article-1-2940-en.html SP - 137 EP - 143 K1 - carotid artery occlusion K1 - forced swimming K1 - herbal extract K1 - malondialdehyde K1 - oxidative stress AB - In patients with cerebral ischemia, both during hospitalization and in the community, the prevalence of major depression is evident. Since the depression has a negative impact on recovery, its timely diagnosis and treatment is essential. This study aimed to evaluate the effect of the oral administration of Chevilan extract (Ferulago angulata hydroalcoholic extract; 100, 200 and 400 mg/kg) on brain oxidative stress indices and depression after permanent bilateral common carotid artery occlusion or ischemia/hypoperfusion in male adult rats. A number of 35 rats were divided into a control group, an ischemic group and ischemic groups receiving doses of 100, 200 and 400 mg/kg of Chevilan extracts for 14 days by gavage. To make animal models of permanent cerebral hypo perfusion/ischemia, right common carotid artery was ligatured first and the left one ligatured with an interval of one week. To evaluate depression, immobility in the forced swimming time of each rat was measured and then the rat’s brain tissues were extracted to separate hippocampus and measure malondialdehyde. The results showed that ischemia/hypoperfusion increased brain oxidants such as lipid per oxidation (LPO) and immobility. Also, ischemic rats treated with all three doses of the Chevilan show significant reduction in the concentration of MDA hippocampus and in immobility time at a dose of 100 mg/kg and 200 / 400mg, respectively. Increased swimming time was observed in all three groups of extract recipients. It was found that Chevilan extract with antioxidant effect can reduce the side effects of ischemia such as depression. LA eng UL http://nbr.khu.ac.ir/article-1-2940-en.html M3 10.29252/nbr.5.2.137 ER -