Association between ERCC5 Gene (SNP: rs2296147 T>C) and the Risk of Breast Cancer in Northwest of Iran

Sadat abbasAbad, Rana; Ghaffarian, Sara

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Ethics code: IR.AZARUNIV.REC.1401.017

Association between ERCC5 Gene (SNP: rs2296147 T>C) and the Risk of Breast Cancer in Northwest of Iran

Rana Sadat abbasAbad

, Sara Ghaffarian ^*

Assistant Professor, Department of Cellular and Molecular Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran , s.ghaffarian@azauniv.ac.ir

Abstract: (607 Views)

ERCC5 gene, is a key components of NER pathway and encodes a key endonuclease. In this study, we analyzed the association between rs2296147 T>C polymorphism of ERCC5 gene with the risk of breast cancer in a case-control study with statistical population consisting of 100 patients and 100 healthy controls by Tetra-ARMS PCR. Statistical analysis was performed using javastat online statistics package and SPSS V.26. The frequency of CC, CT, and TT genotypes in the case group, were 11.46%, 58.33%, and 30.21%, respectively and they were 22%, 44%, and 34% for the control group. Statistical analysis showed a significant association between CC (p-value=0.049) (OR=0.459, CI 95%=0.209-1.007) and CT genotype (p-value=0.045) (OR=1.782, CI 95%=1.012-3.139) with breast cancer risk. Also, C and T alleles frequency in the case group, were 40.62 % and 59.37% and those in the control group were 44 % and 56 % respectively. There was not any significant association between T (p-value=0.499) and C (p-value=0.499) alleles frequency and breast cancer risk in Northwestern Iran. Also, there was no significant association between this SNP frequency and patient’s pathological traits. In conclusion, our study indicated that ERCC5 rs2094258 polymorphism may contribute to the risk of breast cancer in northwestern of Iran.

Keywords: Case-Control study, Nucleotide excision Repair, Pathological traits, Single Nucleotide Polymorphism, ERCC5 gene