تولید واکسن های گیاهی و آزمایش‌های انجام شده در این مورد به عنوان راهبردی مؤثر جهت مقابله با بیماری‌های عفونی از جمله کووید 19

نویسندگان

دانشکده علوم زیستی، دانشگاه خوارزمی، تهران، ایران

چکیده
ظهور ویروس­‌های جدید، همواره تهدیدی برای سلامتی افراد جهان بوده­ است که جدیدترین نمونه آن سویه­‌های جدید ویروس کرونا (SARS-CoV-2) و سندروم حاد تنفسی ناشی از آن (ARDS) است. وضعیت کنونی، اهمیت تولید سریع واکسن‌های پایدار ارزان ­قیمت را که به تجهیزات خنک‌کننده به منظور نگهداری و حمل و نقل نیاز ندارند، بیش از پیش نشان می‌­دهد. با این حال در کشورهای در حال توسعه، بیشتر واکسن­‌ها هنوز به دلیل هزینه­‌های واردات و نیازهای نگهداری و حمل و نقل در دسترس نیستند. بنابراین مهم است که واکسن برای کشورهای در حال توسعه مقرون به صرفه باشد تا واکسیناسیون در مقیاسی وسیع صورت گیرد. واکسن­‌های گیاهی نسبت به سایر انواع واکسن و روش‌­های تولیدی مقرون به‌­صرفه‌­تر هستند و می­توانند در مقادیر زیاد تولید شوند. علاوه­‌بر­این واکسن­‌های گیاهی مزایای دیگری هم دارند که در این مقاله به آنها پرداخته می­شود. با این حال با توجه به اینکه یک محصول دارویی گیاهی قرار است به صورت نیمه فرآوری‌شده (مانند پوره سیب‌زمینی یا رب گوجه‌فرنگی) به­عنوان واکسن مصرف شود، مهم است که بررسی‌های نظارتی خاصی که برای واکسن­های تزریقی اعمال می‌­شود، برای این محصولات نیز اعمال شود تا عوارض مصرف آنها از نظر بالینی بررسی شود. مقاله مروری حاضر به بررسی فرصت‌­ها و چالش‌­های تولید واکسن‌­های گیاهی به منظور مقابله با بیماری­‌هایی مانند کووید 19 می­‌پردازد.




کلیدواژه‌ها


عنوان مقاله English

Plant-based vaccines production and conducted experiments in this case, as an effective strategy to combat infectious diseases, such as Coronavirus disease (COVID-19)

نویسندگان English

Azadeh Niknejad
Alireza Shafizadeh EsfandAbadi
Fatemeh Abdollahi Sarvestani
Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
چکیده English

The emergence of new viruses has always been a threat to the health of people around the world, the latest example of it is the new strains of the coronavirus (SARS-CoV-2) and the resulting acute respiratory distress syndrome (ARDS). The current situation underscores the importance of rapidly producing low-cost stable vaccines that do not require refrigeration equipment for storage and transportation. However, most vaccines are not yet available in developing countries due to import costs and storage and transportation needs. Therefore, the vaccine must be affordable for developing countries so that vaccination can be carried out on a large scale. Herbal vaccines are more cost-effective than other types of vaccines and production methods and can be produced in large quantities. In addition, herbal vaccines have other benefits that are discussed in this article. However, given that an herbal medicinal product is to be used as a vaccine in a semi-processed form (such as mashed potatoes or tomato paste), specific regulatory reviews must apply to injectable vaccines. Products should also be applied to evaluate their side effects clinically. The current review article investigates the opportunities and challenges of producing plant-based vaccines to deal with diseases like Coronavirus disease (COVID-19(.




کلیدواژه‌ها English

Coronavirus disease (COVID-19)
Molecular farming
Oral vaccine
SARS-CoV-2 virus
transgenic plant
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  • تاریخ دریافت 18 خرداد 1405
  • تاریخ انتشار 18 خرداد 1405