بررسی نقش رسپتورهای خانواده D1 وD2 دوپامین در هسته قاعده ای-جانبی آمیگدال بر حافظۀ کاری و مرجع

نویسندگان

1 دانشگاه مازندران، بابلسر

2 دانشگاه مازندران (بابلسر)

چکیده
ناحیه قاعده­ای-جانبی آمیگدال (BLA) جایگاه مهمی در تنظیم نوروترانسمیتری حافظۀ کاری و مرجع است. هدف از مطالعه حاضر بررسی اثر سیستم دوپامینرژیک ناحیه (BLA) بر حافظۀ کاری و مرجعبوده است.موش های صحرایی نر نژاد ویستار با استفاده از دستگاه استرئوتاکسی به صورت دوطرفه در ناحیۀBLA کانول گذاری شد. پارامترهای تعداد خطاهای کاری و مرجع و زمان سپری شده در بازوهای خطاهای کاری و مرجع با استفاده ازدستگاه تست ماز شعاعی و بر اساس پروتکلDSWS مورد محاسبه قرار گرفتند. تزریق آپومورفیندر دوزهای پایین (0.005 µg/rat) و بالا (0.5 µg/rat) درون هسته BLA سبب کاهش معنی داری در تعداد خطاهای کاری و نه مرجع شد که نشان دهنده بهبود حافظۀکاری است. تزریق دوز متوسط آپومورفین (0.05 µg/rat) موجب افزایش تعداد خطاهای کاری و مرجع و مدت زمان سپری شده در بازوهای مذکور شد که نشان دهنده آسیب به هر دو نوع حافظۀ است. تزریق کلرپرومازین (2 µg/rat) ، باعث کاهش خطای کاری و مرجع شد. اما بر مدت زمان سپری شده در بازوهای مربوطه تأثیری نداشت که دلالت بر تقویت حافظه­ های کاری و مرجع دارد. تزریق توامان کلرپرومازین(2 µg/rat) به همراه دوزهای مختلف آپومورفین هیچ تغییر معنی­داری در تعداد خطاهای کاری و مرجع و زمان­های سپری شده در مقایسه با گروه کنترل و گروه دریافت­ کننده کلرپرومازین(2 µg/rat) ایجاد نکرد.یافته های فوق نشان میدهد که سیستم دوپامینرژیک هسته BLA از طریق هردو نوع رسپتور خانواده D1 و D2 در تعدیل حافظه های کاری و مرجع عمل می­کنند. ثانیاً با توجه به سیگنالینگ کاملاً متفاوت درون سلولی این دو نوع رسپتور تأثیر این سیستم در هسته BLA بر حافظۀ کاری و مرجع حاصل برآیند عمل­کرد هردو نوع خانواده رسپتوری است.

کلیدواژه‌ها


عنوان مقاله English

Evaluation of D1 and D2 dopamine receptors families’ role in basolateral amygdala on working and reference memory

نویسندگان English

Farhad Valizadegan 1
Maryam Rahimi Tesyie 2
1 University of Mazandaran, Babolsar
2 University of Mazandaran, Babolsar
چکیده English

The Basolateral Amygdala (BLA) has modulatory effects on working and reference memory. The aim of this study was the evaluation of effects of dopaminergic system in the BLA of rats on working and reference memory behaviors. The number of working and reference errors and time spent in the arms by rats were measured in the radial arm maze according to DSWS protocol. The animals were cannulated in the BLA bilaterally. The microinjection of low dose (0.005µg/rat) and high dose (0.5 µg/rat) of apomorphine have indicated a significant decrease in number of working memory error. But, there was not any change in the numberof reference memory error that showing the improvement of working memory. While the injection of moderate dose apomorphine (0.05 µg/rat) increased these parameters and also enhanced the spent time in working arm that presenting both memories damage. The chlorpromazine injection (2 µg/rat) decreased the number of working and reference memory errors representing the improvement of these memories. Microinjection of chlorpromazine (2 µg/rat) with different doses of apomorphine had no significant change on the both number of errors and the time spent in comparison with control groups. These findings show that BLA dopaminergic system modulates the working and reference memory through that both of (D1/D2) receptors. Also, the effect of this system in BLA is the resultant function of the both receptor families.

کلیدواژه‌ها English

apomorphine
chlorpromazine
dopaminergic system
radial arm maze
rat
Aalto, S., Brück, A., Laine, M., Någren, K. and Rinne, J.O. 2005. Frontal and temporal dopamine release during working memory and attention tasks in heal-thy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C] FLB 457. –J. Neurosci. 25: 2471-2477.
Adlersberg, M., Hsiung, S., Sara, B., Liu, K., Tamir, H. and Schmauss, C. 2004. Regulation of dopamine D1-receptor activation in vivo by proteinphosphatase 2b (calcineurin). – J. Neurochem. 90: 865-873.
Arnsten, A.F. and Goldman-Rakic, P.S. 1998. Noise stress impairs prefrontal cortical cognitive function in monkeys: Evidence for a hyperdopaminergic mecha-nism. – Arch. Gen. Psychiatry. 55: 362-368.
Baddeley, A. 2000. The episodic buffer: a new compo-nent of working memory? – Trends Cogn. Sci. 4: 417-423.
Baddeley, A.D. and Hitch, G. 1974. Working memory. – Psychol. Learn Motiv. 8: 47-89.
Barrot, M., Sesack, S.R., Georges, F., Pistis, M., Hong, S. and Jhou, T.C. 2012. Braking dopamine systems: a
new GABA master structure for mesolimbic and nigrostriatal functions. – J. Neurosci. 32: 14094-14101.
Birnbaum, S.G., Yuan, P.X., Wang, M., Vijay-raghavan, S., Bloom, A.K., Davis, D.J. and Arnsten, A.F.T. 2004. Protein kinase coveractivity impairs prefrontal cortical regulation of working memory. – Science 306: 882-884.
Björklund, A. and Dunnett, S.B. 2007.Dopamine neuron systems in the brain: an update. – Trends Neurosci. 35: 194-202.
Bloch, B., Dumartin, B. and Bernard, V. 1999. In vivo regulation of intraneuronal trafficking of G protein-coupled receptors for neurotransmitters. – Trends Pharmacol. Sci. 20: 315-319.
Bourdy, R. and Barrot, M. 2012. A new control center for dopaminergic systems: pulling the VTA by the tail. –Trends Neurosci.35: 681-690.
Cador, M., Robbins, T.W. and Everitt, B.J. 1989. Invol-vement of the amygdala in stimulus-reward associ-ations: interaction with the ventral striatum. – Neurosci. 30: 77-86.
Childers, S.R., Sexton, T. and Roy, M.B. 1994. Effects of anandamide on cannabinoid receptors in rat brain members. – Biochem. Pharmacol. 47: 711-715.
Damasio, A.R. 1994. Descartes’ error. emotion, reason and the human brain. – New York (Grosset-/Putnam).
Dash, P.K., Moore, A.N., Kobori, N. and Runyan, J.D. 2007. Molecular activity underlying working memory. – Learn Mem. 14: 554-563.
Davis, M. 1992. The role of the amygdala in fear and anxiety. – Annu. Rev. Neurosci. 15: 353-375.
Del Arco, A. and Mora, F. 2009. Neurotransmitters and prefrontal cortex–limbic system interactions: implic-ations for plasticity and psychiatric disorders. – J. Neural. Transm. 116: 941-952.
Eichenbaum, H. and Cohen, N.J. 2004. From condit-ioning to conscious recollection: memory systems of the brain (No. 35). – Oxford University Press on Demand. pp 600.
Fadok, J.P., Dickerson, T.M. and Palmiter, R.D. 2009. Dopamine is necessary for cue-dependent fear condi-tioning. – J. Neurosci. 29: 11089-11097.
Fuster, J.M. 1989. The prefrontal cortex. – New York: Raven Press
Fuster, J.M. 2001. Memory networks in the prefrontal cortex. – Prog. Brain Res. 122: 309-316.
Fuster, J.M., Bauer, R.H. and Jervey, J.P. 1985. Func-tional interactions between inferotemporal and pref-rontal cortex in a cognitive task. – Brain Res. 330: 299-307.
Fuster, J.M. and Jervey, J.P. 1982. Neuronal firing in the inferotemporal cortex of the monkey in a visual memory task. – J. Neurosci. 2: 361-375.
Gaffan, D., Murray, E.A. and Fabre‐Thorpe, M. 1993. Interaction of the amygdala with the frontal lobe in reward memory. – Eur. J. Neurosci. 5: 968-975.
Gallagher, M. and Holland, P. 1994. The amygdala complex: multiple roles in associative learning and attention. – Proc. Natl. Acad. Sci. 91: 11771-11776.
Garcia R, Vouimba, RM, Baudry, M., and Thompson, R.F. 1999. The amygdala modulates prefrontal cortex activity relative to conditioned fear. – Nature 402: 294-296. Glicksteins, B. and Schmauss, C. 2001. Dopamine receptor functions: lessons from knockout mice. – Pharmacol. Ther. 91: 63-83.
Greba, Q., Gifkins, A. and Kokkinidis, L. 2001. Inhibition of amygdaloid dopamine D 2 receptors impairs emotional learning measured with fear-potentiated startle. – Brain Res. 899: 218-226.
Greba, Q. and Kokkinidis, L. 2000. Peripheral and intra-amygdalar administration of the dopamine D₁ receptor antagonist SCH 23390 blocks fear-poten-tiated startle but not shock reactivity or the shock sensitization of acoustic startle. – Behav. Neurosci. 114: 262-72.
Guarraci, F.A., Frohardt, R.J., Falls, W.A. and Kapp, B.S. 2000. The effects of intra-amygdaloid infusions of a D1 dopamine receptor antagonist on Pavlovian fear conditioning. –Behav. Neurosci. 114: 647-651.
Guarraci, F.A., Frohardt, R.J. and Kapp, B.S. 1999. Amygdaloid D1 dopamine receptor involvement in Pavlovian fear conditioning. – Brain Res. 827: 28-40.
Hikosaka, O. and Sakamoto, M. 1986. Cell activity in monkey caudate nucleus preceding saccadic eye movements. – Exp. Brain Res. 63:659-662.
Hikosaka, O., Sakamoto, M. and Usui, S., 1989. Functional properties of monkey caudateneurons. I. activities related to saccadic eye movements. – J. Neurophysiol. 61:780-798.
Holstege, G., Georgiadis, J.R., Paans, A.M., Meiners, L.C., van der Graaf, F.H. and Reinders, A.S. 2003. Brain activation during human male ejaculation. – J. Neurosci. 23: 9185-9193.
Honig, W.K. 1978. Studies of working memory in the Pigeon.In “cognitive processes in animal behavior”, SH. Hulse, H. Fowler and WK. Honig.
Jackson, M.E. and Moghaddam, B. 2001. Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal cortex. – J. Neurosci. 21: 676-681.
Jiang, D. and Sibley, D. 1999. Regulation of D1 dopa-mine receptors with mutations of protein kinase phosphorylation sites: Attenuation of the rateofa-gonist-induced desensitization. – Mol. Pharmacol. 56: 675-683.
Jin, L.Q., Goswami, S., Cai, G., Zhen, X. and Friedman, E. 2003. SKF83959 selectively regulates phosph-atidylinositol‐linked D1 dopamine receptors in rat brain. – ‎J. Neurochem. 85: 378-386.
Klein J., Winter C., Coquery N., Heinz A., Morgenstern R., Kupsch A., Juckel G. 2010. Lesion of the medial prefrontal cortex and the subthalamic nucleus selec-tively affect depression-like behavior in rats. – Behav. Brain Res. 213: 73-81.
LeDoux, J. 1992.Brain mechanisms of emotion and emotional learning. – Curr. Opin. Neurobiol. 2: 191-198.
Lidow, M.S., Goldman-Rakic, P.S., Gallager, D.W., and Rakic, P. 1991. Distribution of dopaminergic rece-ptors in the primate cerebralcortex: Quantitative auto-radiographic analysis using [3H] raclopride, [3H] spiperone and [3H] SCH23390. – Neurosci. 40: 657-671.
Malenka, R.C., Nestler, E.J. and Hyman, S. E. 2009. Widely projecting systems: monoamines, acety-lcholine, and orexin. Sydor A, Brown RY. Molecular Neuropharmacology: a foundation for clinical neuro-science (2nd ed.). – New York: McGraw-Hill Medical, 147-148.
McDonald, A.J. 1987. Organization of amygdaloid projections to the mediodorsal thalamus and prefro-ntalcortex: a fluorescence retrograde transport study in the rat. – J. Comp. Neurol. 262: 46-58.
Miller, E.K., Li, L. and Desimone, R. 1991. A neural mechanism for working and recognition memory in inferior temporal cortex. – Science 254: 1377-1379.
Miller, E.K., Li, L. and Desimone, R. 1993. Activity of neurons in anterior inferior temporal cortex during a short-term memory task. – J. Neurosci. 13: 1460-1478.
Milner, B. 1964. Some effects of frontal lobectomy in man. In: Warren JM, Akert K, editors. The frontal agranular cortex and behavior. – McGraw-Hill, New York, pp313-34.
Milner, B., Petrides, M. and Smith, M.L. 1985. Frontal lobes and the temporal organization of memory. – Hum. Neurobiol. 4:137-42.
Mogenson, G.J., Jones, D.L. and Yim, C.Y. 1980. From motivation to action: functional interface between the limbic system and the motor system. – Prog. Neurobiol. 14: 69-97. Mora, M., Gallegos-Cari, A., Arizmendi-Garc, Y., Marcellino, B. and Fuxe, K. 2010. Role of dopamine receptormechanisms in the amygdaloidmodulation of fear and anxiety: structural and functional analysis. – Progress in Neurobiology. 90 198-216.
Nader, K. and LeDoux, J. 1999. Inhibition of the mesoa-mygdala dopaminergic pathway impairs the retrieval of conditioned fear associations. – Behav. Neurosci. 113: 891
Nechifor, M. 2008. Magnesium in drug dependences. – Magnes. Res. 21: 5-15.
Olton, D.S., Becker, J.T. and Handelmann, G.E. 1979. Hippocampus, space, and memory. – Behav. Brain Sci. 2: 313-322.
Owen, A.M., Downes, J.J., Sahakian, B.J., Polkey, C.E. and Robbins, T.W. 1990. Planning and spatial work-ing memory following frontal lobe lesions in man. – Neuropsychology 28:1021-1034.
Packard, M.G. and White, N.M. 1990. Lesions of the caudate nucleus selective "reference memory" acquisition in the radial maze. – Behav. Neural Biol.53: 39-50.
Paxinos, G. and Watson, C. 2007. The rat brain in stereotaxic coordinates. 6th ed. – San Diego, CA: Academic Press.
Phillips, A.G., Ahn, S. and Floresco, S.B. 2004. Magn-itude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task. – J. Neurosci. 24: 547-553.
Pierce, K.L., Premont, R.T. and Lefkowitz, R.J. 2002. Seven-transmembrane receptors. – Nat. Rev. Mol. Cell Biol. 3: 639-650.
Runyan, J.D. and Dash, P.K. 2005. Distinct prefrontal molecular mechanisms for information storage lasting seconds versus minutes. – Learn. Mem. 12: 232-238.
Runyan, J.D., Moore, A.N. and Dash, P.K. 2005. A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory. – Learn. Mem.12: 103-110.
Sherman, S.M. and Guillery, R.W. 2002. The role of the thalamus in the flow of information to the cortex. – Philosophical Transactions of the Royal Society of London B: Biol. Sci. 357: 1695-1708.
Spinnler, H., Della, Sala, S., Bandera, R. and Baddeley, A.D. 1988. Dementia, ageing and the structure of human memory. – Cogn. Neuro. Psychol. 5:193-211.
Taylor, C.L., Latimer, M.P. and Winn, P. 2003. Impaired delayed spatial win-shift behavior on the eight arm radial maze following excitotoxic lesions of the medial prefrontal cortex in the 264 rat. – Behav. Brain Res.147: 107-114.
Williams, G.V. and Goldman-Rakic, P.S. 1995. Modu-lation of memory fields by dopamine D1 receptors in prefrontal cortex. – Nature 376:572-575.
Zahrt, J., Taylor, J.R., Mathew, R.G. and Arnsten, A.F. 1997. Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance. – J. Neurosci. 17: 8528-8535.
Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B.D., Miyakawa, T., Bear, M.F. and Toneg-awa S. 2001. Forebrain specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic–like memory. – Cell 107: 617-629.

  • تاریخ دریافت 18 خرداد 1405
  • تاریخ انتشار 18 خرداد 1405