TY - JOUR T1 - Effect of Urtica dioica hydroalcoholic extract on liver inflammatory factors in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate TT - بررسی تأثیرات عصارۀ هیدروالکلی گیاه گزنه بر فاکتورهای التهابی کبدی رت های ویستار مبتلا به سندرم تخمدان پلی کیستیک القاشده با استرادیول والرات JF - nbr JO - nbr VL - 4 IS - 2 UR - http://nbr.khu.ac.ir/article-1-2953-en.html Y1 - 2017 SP - 181 EP - 188 KW - fatty liver KW - inflammation KW - ovary KW - ELISA N2 - The polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women at childbearing age. Metabolic syndrome is present from 28% to 46% of patients with PCOS. Non-alcoholic fatty liver di-sease (NAFLD) is considered the hepatic expression of metabolic syndrome. In this study Urtica dioica moderator ef-fect on liver function in PCOS rats was examined. 120 adult female Wistar rats were divided into control, PCOS and nettle-treated groups. The PCOS group was injected subcutaneously 2 mg/kg estradiol valerate. After confirmed poly-cystic in ovaries, the experimental group was injected of the nettle extract doses (150,250, 450 mg/kg BW). Then rats were killed and blood samples were evaluated. Data were analyzed using ANOVA one-way and p<0.05 was considered statistically significant. ELISA test showed a decrease in IL-6 level and CRP levels reduced in PCOS rats were treated with various concentrations of nettle. Our results show that nettle due to its antioxidant properties reduce the levels of IL-6 and CRP in nettle extract treated-PCOS compared to the PCOS. M3 10.21859/acadpub.nbr.4.2.181 ER -