%0 Journal Article %A Tayanloo, Akram %A Zare1, Samad %A Karimzadeh-Bardei, Latifeh %A Hoseini, Serwa %T Effect of Urtica dioica hydroalcoholic extract on liver inflammatory factors in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate %J Nova Biologica Reperta %V 4 %N 2 %U http://nbr.khu.ac.ir/article-1-2953-en.html %R 10.21859/acadpub.nbr.4.2.181 %D 2017 %K fatty liver, inflammation, ovary, ELISA, %X The polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women at childbearing age. Metabolic syndrome is present from 28% to 46% of patients with PCOS. Non-alcoholic fatty liver di-sease (NAFLD) is considered the hepatic expression of metabolic syndrome. In this study Urtica dioica moderator ef-fect on liver function in PCOS rats was examined. 120 adult female Wistar rats were divided into control, PCOS and nettle-treated groups. The PCOS group was injected subcutaneously 2 mg/kg estradiol valerate. After confirmed poly-cystic in ovaries, the experimental group was injected of the nettle extract doses (150,250, 450 mg/kg BW). Then rats were killed and blood samples were evaluated. Data were analyzed using ANOVA one-way and p<0.05 was considered statistically significant. ELISA test showed a decrease in IL-6 level and CRP levels reduced in PCOS rats were treated with various concentrations of nettle. Our results show that nettle due to its antioxidant properties reduce the levels of IL-6 and CRP in nettle extract treated-PCOS compared to the PCOS. %> http://nbr.khu.ac.ir/article-1-2953-en.pdf %P 181-188 %& 181 %! %9 Original Article %L A-10-81-70 %+ Urmia University %G eng %@ 2423-6330 %[ 2017