TY - JOUR JF - nbr JO - NBR VL - 4 IS - 4 PY - 2018 Y1 - 2018/3/01 TI - Protective effect of Arctium lappa on oxidative stress and nephrotoxicity induced by gentamicin TT - اثر حمایتی گیاه باباآدم بر استرس اکسیداتیو و مسمومیت القاشده با جنتامایسین N2 - This study aimed to investigate the protective effect of Arctium lappa (AL) on gentamicin (GM)-induced nephrotoxicity in rats. Twenty-four Wistar rats were divided into four groups including: control group; GM group (intrapritoneal injection, IP, of 100 mg/kg GM B.W.); GM+AL group (received IP injection of 100 mg/kg GM and 500 mg/kg AL orally) and AL group (received 500 mg/kg AL orally). The experimental period lasted for 10 days. Nephrotoxicity was biochemically and histologically evaluated. The concentrations of creatinine, urea, malondialdehyde (MDA), superoxide dismutase (SOD) and peroxide hydrogen (H2O2) in the serum samples were determined. Moreover, histological examinations were performed. The animals treated with gentamicin showed significantly higher serum urea, creatinine, MDA and H2O2 levels and lower SOD activity. However, co-administration of AL produced amelioration in biochemical indices of nephrotoxicity in serum. Histomorphological examination showed necrosis and desquamation of tubular epithelial cells in the renal cortex in animals treated with gentamicin whereas simultaneous administration of AL and GM reduced histological damages. The data obtained suggest that treatment with AL extract can help to reduce gentamicin-induced nephrotoxicity. SP - 353 EP - 360 AU - Yari, Siamak AU - Karamian, Roya AU - Asabbeigi, Mostafa AU - Namdari, Ali AD - Bu-Ali Sina University, Hamedan KW - creatinine KW - hydrogen peroxide KW - kidney tissue KW - malondialdehyde KW - rat UR - http://nbr.khu.ac.ir/article-1-3057-en.html DO - 10.29252/nbr.4.4.353 ER -